Group Members

portrait

David Nannemann

Former Post-Doctoral Fellow

B.S., Hardin-Simmons University
david.p.nannemann [ at ] vanderbilt.edu

Research Interests:

Enzymes perform an interesting array of chemical reactions but are  limited by substrate specificities. Computational methods allow for  quick in silico screening of multi-mutant enzymes easing the burden in  the wet-lab. Work is oriented towards application of RosettaLigand to  switch substrate specificity and impart catalytic function on novel, non-natural substrates.


  • Research Projects
  • Publications
David P. Nannemann;Kristian Kaufmann, Jens Meiler, Brian Bachmann
Design and directed evolution of a dideoxy purine nucleoside phosphorylase (2010) Protein Engineering

Mohammed S. Aiyegbo;Gopal Sapparapu, Benjamin W. Spiller, Ilyas M. Eli, Dewight R. Williams, Robert Kim, David E. Lee, Tong Liu, Sheng Li, Virgil L. Woods Jr, David P. Nannemann, Jens Meiler, Phoebe L. Stewart, James E. Crowe Jr
Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore (2013) PLOS One

Steven A Combs;Samuel L DeLuca, Stephanie H DeLuca, Gordon H Lemmon, David P Nannemann, Elizabeth D Nguyen, Jordan R Willis, Jonathan H Sheehan, Jens Meiler
Small-molecule ligand docking into comparative models with Rosetta (2013) Nature Protocols

Thornburg NJ;Nannemann DP, Blum DL, Belser JA, Tumpey TM, Deshpande S, Fritz GA, Sapparapu G, Krause JC, Lee JH, Ward AB, Lee DE, Li S, Winarski KL, Spiller BW, Meiler J, Crowe JE Jr.
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses (2013) J Clin Invest

Natalie J. Thornburg;David P. Nannemann, David L. Blum, Jessica A. Belser, Terrence M. Tumpey, Shyam Deshpande, Gloria A. Fritz, Gopal Sapparapu, Jens C. Krause, Jeong Hyun Lee, Andrew B. Ward, David E. Lee, Sheng Li, Katie L. Winarski, Benjamin W. Spiller, Jens Meiler, and James E. Crowe, Jr.
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses (2013) J Clin Invest