Computational Chemical and Structural Biology
Former Post-Doctoral Fellow
B.S., Hardin-Simmons University
david.p.nannemann [ at ] vanderbilt.edu
Enzymes perform an interesting array of chemical reactions but are limited by substrate specificities. Computational methods allow for quick in silico screening of multi-mutant enzymes easing the burden in the wet-lab. Work is oriented towards application of RosettaLigand to switch substrate specificity and impart catalytic function on novel, non-natural substrates.