Group Members

portrait

Georg Kuenze

Current Post-Doctoral Fellow

PhD in Biochemistry University of Leipzig, Germany
georg.kuenze [ at ] vanderbilt.edu
Vanderbilt University - MBRIII 5140 Office Suite

Research Interests:

  • Protein Structure Prediction
  • Biomolecular NMR Spectroscopy
  • Integrative Modeling
  • Membrane Proteins
  • Ion Channels



My research area is focused at the interface of computational structural biology and biophysics. I am exploring the structural and functional properties of proteins by a combination of computational and biophysical tools including molecular modeling, NMR and MD simulations. My long-term focus is dedicated to ion channels which facilitate the movement of ions across lipid bilayers and play crucial roles in many areas of cellular life. I am currently investigating the voltage-gated K+ channel KCNQ1, which is important for proper repolarization of the cardiac action potential. Mutations in KCNQ1 can lead to several cardiac diseases such as atrial fibrillation or long-QT syndrome. Using computational modeling and machine learning, I aim to answer questions related to the molecular mechanisms of KCNQ1 gating, the transition between closed and open channel states, beta-subunit regulation, and the role of mutations in KCNQ1. To accomplish these goals, my research also involves the development of new modeling methods for the Rosetta software suite for its application to protein structure determination and design.

Publication List:


https://scholar.google.com/citations?user=YlfYXKEAAAAJ&hl=en